Here is their justification. The likelihood of amyloidogenic APP increases with its phosphorylation, conversely a state by protein phosphatase 2A itself itself affected by methylation. Previous studies have also reported downregulation of neuronal PP2A methyltransferase and reduced PP2A methylation in the brain tissue of Alzheimer’s patients. In these same cells, phosphorylation of tau and APP has been improved.. In mice of PP2A and tau / APP phosphorylationEstelle Sontag, Viyada Nunbhakdi – Craig, Jean-Marie Sontag, Ramon Diaz – Arrastia, Egon Ogris, Sanjana Dayal, Steven R.
However, further investigations on the applicability of this quaternary classification of patients in other regions are required.Reference: Gong JQ, Tian FZ, Jiang R, Tang LJ, management of patients with sphincter of Oddi dysfunction to a new classification.[ iv] Chaudhuri, The Parkinson’s disease bed scale: a new instrument for the assessment of bed and nightly disability in Parkinson’s disease. J Neurol Neurosurg Psychiatry 2002, 73: 629-635.
[ iii] Stocchi, F et al. Editors. The Reallife, Real PD Survey, Pan-European results and recommendations for change. Abstract online.