The first phase Tyrima II trial is enrolled a double-blind, placebo-controlled, multi-center study on 270 patients expected with major depressive disorder . The trial is expected to to begin later this quarter. – Tyrima worked with a drug with promising antidepressant properties and CeNeRx with leading PET imaging experts at Brookhaven National Laboratory to produce comprehensive data on the plasma levels of Tyrima affect pathways in the brain, said K. Ranga Krishnan, tomography, Chairman, Department of Psychiatry and Behavioral Sciences at Duke University Medical Center, and CeNeRx SAB member. An agent such as Tyrima with proven MAOI activity in the CNS and a good tolerability could be affected a valuable new treatment option for patients of depression. Successful completion this PET imaging coupled study with the positive results of the Phase I program, support progression of Tyrima phase phase II studies. .

Like conventional MAOI agents, highlights the triple – action mechanism of Tyrima the levels of three key neurotransmitters In contrast, mood and anxiety In contrast, most current antidepressant drugs affect only a single neurotransmitter. But unlike these older MAOIs, the selectivity and reversibility of Tyrima should enable patients to benefit from the advantages of the class effectiveness while avoiding the food – associated cardiovascular side effects of conventional MAOIs that have greatly restricted their use.

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